Clinical Profile of COVID-19 Patients Admitted in a COVID Designated Hospital

Pukar Ghimire; Anuradha Pokharel; Prakash Aryal; Rajan Bhandari; Bibek Bhandari

doi:10.33314/jnhrc.v19i3.3649

Pukar Ghimire Department of Internal Medicine, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal https://orcid.org/0000-0002-5834-2607
Anuradha Pokharel Department of Internal Medicine, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal
Prakash Aryal Department of Internal Medicine, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal http://orcid.org/0000-0002-5580-1345
Rajan Bhandari Department of Internal Medicine, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal https://orcid.org/0000-0001-9721-6198
Bibek Bhandari Department of Internal Medicine, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal http://orcid.org/0000-0002-2732-6508

DOI: https://doi.org/10.33314/jnhrc.v19i3.3649

Abstract

Background: Pandemic of COVID-19 has engulfed Nepal as well. In this paper, we studied the demographic, clinical, laboratory findings as well as the treatment modalities, prognostic factors and outcome of patients admitted with COVID-19.
Methods: This was an observational cross-sectional study that included all patients admitted to the General Medicine Department of College of Medical Sciences, Bharatpur, during the first wave of COVID-19 from April 2020 to February 2021 after obtaining the ethical clearance. Data analysis was done using statistical packages for social sciences version 16.
Results: A total of 119 patients with mean age of 61.5 years were admitted. They had a mean duration of onset of symptoms of 7.1 days. Commonest symptoms were fever (70.6%), cough (67.2%) and dyspnea (64.7%). Severe COVID-19 at admission with a median CT severity score of 15 was found in 49.7% of them. Total 83.2% patients required ICU care and 10.9% required mechanical ventilation. ARDS and secondary infection occurred in 17.6% each. Median length of hospital stay was 6 days. In total, 56.3% recovered 27.7% left against medical advice and 16.0% expired. Severity of COVID at admission, CT severity score at presentation and D-dimer at admission were found to be significantly associated with mortality (P<0.05).Neither of the age, duration of illness, CRP at admission nor the use of remdesivir or convalescent plasma had significant relation with the mortality (P>0.05).
Conclusions: Severity of illness at presentation, CT severity score and D-dimer level at admission are significantly associated with mortality of the patients admitted with COVID-19.
Keywords: COVID-19; prognosis; SARS-CoV-2