Analysis of Homocysteine Level in Patient with Acute Kidney Injury

Abstract

Background: Homocysteine (Hcy) contributes to oxidative stress and renal injury by generating reactive oxygen species and reducing heme oxygenase-1 levels. Elevated Hcy (Hhcy) may worsen outcomes after acute renal failure(ARF), promoting fibrosis and progression to chronic kidney disease (CKD). This study investigates the association between Hcy levels and ARF in patients at Tribhuvan University Teaching Hospital.
Methods: This study was an analytical cross sectional single center study that was carried out in Tribhuvan University Teaching Hospital. Specimens were processed as per the guidelines of Standard Operating Procedure (SOP) of Biochemistry laboratory of Tribhuvan University Teaching Hospital.
Results: Participants had a mean age of 54.2 years. Mean homocysteine was (13.7±10.36) µmol/L and creatinine was (148.7±18.03) µmol/L. Homocysteine levels showed no significant association with age, sex, residence, or disease type. A weak but significant positive correlation was found between homocysteine and creatinine(r = 0.186, p = 0.029). Potassium correlated moderately with creatinine (r = 0.383, p< 0.001).
Conclusions: Homocysteine levels showed no significant association with age, gender, residence, or comorbid conditions. A weak but significant correlation was observed between homocysteine and creatinine, suggesting a potential link with renal function.
Keywords: Creatinine; homocysteine; potassium; renal failure.